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目的评价中晚期胃癌术前新辅助化疗的作用。方法总结2003年至2008年间92例入院后经CT、B超、胃镜等检查后诊断为中晚期胃癌并通过新辅助化疗后再行手术治疗的病例,并与2000年至2002年间收治的未经新辅助化疗的中晚期胃癌49例对照分析。结果化疗组肿瘤缩小或明显缩小者66例(71.7%),行根治性手术切除者69例(75%),行局部切除者17例(18.5%),姑息性手术者6例(6.5%)。对照组行根治性手术切除者24例(48.9%),行局部切除者15例(30.6%),姑息性手术者10例(20.4%)。所有病例均术后经病理证实,化疗组Ⅲa期46例,Ⅲb期33例,Ⅳ期13例,对照组Ⅲa期25例,Ⅲb期16例,Ⅳ期8例。结论对于以往手术切除较为困难或根治率低的中晚期胃癌,术前配合新辅助化疗,可提高手术切除率及根治率。
Objective To evaluate the effect of neoadjuvant chemotherapy in advanced gastric cancer. Methods The clinical data of 92 cases diagnosed as advanced gastric cancer after neoadjuvant chemotherapy by CT, B-ultrasound and gastroscopy after admission from 2003 to 2008 were retrospectively analyzed and compared with those without concomitant treatment Neoadjuvant Chemotherapy in Advanced Gastric Cancer: A Comparative Analysis of 49 Cases. Results In the chemotherapy group, there were 66 cases (71.7%) with reduced or significantly reduced tumors, 69 cases (75%) with radical resection, 17 cases (18.5%) with partial resection and 6 cases (6.5%) with palliative surgery . In the control group, 24 patients (48.9%) underwent radical resection, 15 (30.6%) underwent partial excision and 10 (20.4%) palliative surgeries. All the cases were confirmed by pathology. The patients in stage Ⅲa were 46 cases, stage Ⅲb in 33 cases, stage Ⅳ in 13 cases, control group in stage Ⅲa in 25 cases, stage Ⅲb in 16 cases and stage Ⅳ in 8 cases. Conclusions For patients with advanced gastric cancer who had more difficult surgical resection or low cure rate, preoperative neoadjuvant chemotherapy can improve the resection rate and cure rate.