论文部分内容阅读
本文研究了添加剂,包括吸附剂、表面活性剂、稀释剂及润滑剂对氯霉素溶解速率的影响。系采用一种新的载体体系:在药物和吸附剂混合物中加入有机溶剂,使药物溶解。再将溶剂挥发,使药物微粒以分子状态沉积于吸附剂表面,形成共沉淀物制成胶囊,比较添加剂种类、溶剂及制备方法对氯霉素从胶囊中溶出速率。其结果为不同极性的Aerosil(Ⅰ)、(Ⅱ)、(Ⅲ)用丙酮作溶剂时,溶解速率大于用丙酮与氯仿为溶剂,不同Aerosil溶解速率增加次序为(Ⅲ)>(Ⅱ)>(Ⅰ)。用物理混合的方式加入吐温80或十二烷基硫酸钠及天然表面活性剂脱氧胆酸钠和
This article studies the effect of additives, including adsorbents, surfactants, thinners, and lubricants on the rate of chloramphenicol dissolution. A new carrier system is used: adding an organic solvent to the mixture of drug and adsorbent to dissolve the drug. Then the solvent is volatilized so that the drug particles are deposited on the surface of the adsorbent in a molecular state to form a coprecipitate to form a capsule. The types of the additives, the solvents and preparation methods are compared to determine the dissolution rate of the chloramphenicol capsules from the capsules. The results showed that the dissolution rates of Aerosil (Ⅰ), (Ⅱ) and (Ⅲ) with different polarities were higher than those with acetone and chloroform. The increasing order of the Aerosil (Ⅰ), (I). Tween 80 or sodium lauryl sulfate and natural surfactant sodium deoxycholate were added by physical mixing and