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头孢哌酮钠(cfoperazone,CPZ)为头孢哌酮的钠盐,是目前较为常用的第三代头孢菌素类抗生素,临床在与10％葡萄糖输液(10％G·S)混合应用中,偶尔会产生混浊或白色沉淀现象。头孢哌酮极微溶于水,pH值为2.00～4.00;而其钠盐极易溶于水,pH值为4.50～6.50。因此推断当CPZ与pH值较低的10％G·S(pH值3.50～5.50)混合时,随着混合溶液的pH值降低可使部分头孢哌酮游离出来,从而产生混浊或沉淀。笔者考查了10％G·S的pH值对CPZ溶解度影响,以供临床用药参考。
As a third-generation cephalosporin antibiotic, cefoperazone sodium (CPZ) is the sodium salt of cefoperazone. Occasionally, it causes turbidity when it is mixed with 10% glucose infusion (10% G · S) Or white precipitation phenomenon. Cefoperazone is very slightly soluble in water with a pH value of 2.00-4.00; while its sodium salt is very soluble in water with a pH of 4.50-6.50. Therefore, it is inferred that when CPZ is mixed with 10% G · S (pH value 3.50 ~ 5.50) with a lower pH value, part of cefoperazone will be released as the pH value of the mixed solution decreases, resulting in turbidity or precipitation. The author examined the pH of 10% G · S solubility of CPZ for clinical reference.