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免疫对象300人双盲随机分组,分别接种中、美三种乙型肝炎疫苗。二次接种后的结果:三种疫苗接种后反应均轻微,安全性好。初次及第二次接种后,中国血源疫苗抗HBs的阳转率为42.2%和64.0%,美国Merck基因疫苗为49.5%和86.7%,Merck血源疫苗为53.0%和77.8%。中国血源疫苗的抗体水平P/N值在50以下而Merke二种疫苗超过50以上。
Three hundred people were randomized to double-blind immunization, and three kinds of hepatitis B vaccine were respectively inoculated in China and the United States. The results after the second inoculation: The responses of the three vaccines are slight and the safety is good. After the first and second vaccination, the positive rate of anti-HBs of Chinese blood-borne vaccines was 42.2% and 64.0%, that of Merck gene vaccines of the United States was 49.5% and 86.7%, and that of Merck’s blood-borne vaccines was 53.0% and 77.8% respectively. Antibody levels for Chinese blood-borne vaccines were below 50 P / N and over 50 for both Merke vaccines.