目的:探讨常规IVF受精失败患者再次周期行ICSI-ET治疗时,卵子因素对胚胎结局的影响。方法:回顾分析因前次IVF-ET中受精障碍或受精率≤30%而行ICSI治疗的38个周期(A组)和因严重精液异常而行ICSI治疗的181个周期(B组)的ICSI结局。结果:A、B组的受精率(FR)、卵裂率(CR)、胚胎利用率(URE)、胚胎着床率(EIR)、临床妊娠率(CPR)和早期流产率(EAR)分别为82.5%vs78.0%(P<0.05),97.5%vs97.6%(P>0.05),76.4%vs73.1%(P>0.05),10.0%vs19.8%(P<0.05),27.0%vs31.8%(P>0.05),40.0%和16.1%(P>0.05)。结论:常规IVF-ET受精失败的患者,再次周期行ICSI-ET治疗,受精率提高,由于卵子异常对胚胎发育的不利影响,部分胚胎着床和着床后的远期发育潜能降低。 OBJECTIVE: To investigate the effect of egg factors on embryonic outcome in ICSI-ET treatment in patients with failed IVF fertilization. Methods: We retrospectively analyzed 38 ICSI-treated cycles (group A) and 181 cycles (group B) of ICSI treated with severe semen abnormalities (group B) due to previous fertilization or fertilization rates ≤30% in IVF-ET ending. Results: The fertilization rate, cleavage rate, embryo utilization rate, embryo implantation rate, clinical pregnancy rate and early abortion rate in group A and B were 82.5% vs78.0% (P <0.05), 97.5% vs97.6% (P> 0.05), 76.4% vs73.1% (P> 0.05), 10.0% vs19.8% (P <0.05) vs 31.8% (P> 0.05), 40.0% and 16.1% (P> 0.05). CONCLUSIONS: ICSI-ET treatment is performed again in patients who have failed IVF-ET fertilization. The fertilization rate is increased. Due to the adverse effects of abnormal ovum on embryo development, some embryos have impaired developmental potential after implantation and implantation.