报告 1例胫前粘液性水肿合并甲状腺功能亢进。 4年来的症状、体征以及实验室检查示：心悸，双眼突出，体重减轻。近 2年来出现双下肢高低不平的蜡样结节、斑块，毛孔粗大，非凹陷性水肿。双侧结节性甲状腺肿，血清 T3、 TT4水平异常增高。皮损部位组织病理检查显示大量粘蛋白沉积于真皮，出现真皮增厚和胶原纤维束分离。 Report of 1 case of anterior tibial myxedema with hyperthyroidism. 4 years of symptoms, signs and laboratory tests showed: palpitations, eyes prominent, weight loss. In the past two years there have been uneven waxy nodules in both lower extremities, with plaque, large pores and non-pitting edema. Bilateral nodular goiter, serum T3, TT4 levels were abnormally increased. Histopathological examination showed that a large number of mucin deposits in the dermis, dermis thickening and collagen fiber bundle separation.