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动物实验证明氨基糖苷类抗生素每日单次给药比每日同量分2～3次注射或连续静脉滴注可能对肾脏和内耳的损害更小。已有关于庆大霉素在治疗尿路感染中一次给药与多次给药的疗效相等的报告。乙基西索米星的耳肾毒性低于其它氨基糖苷类。作者认为用其单剂量方案治疗全身感染似乎适于检验它的疗效和安全性。作者从1985年11月～1986年8月对40例坏疽性和穿孔性阑尾炎手术病人进行随机研究。A组20名病人,接受乙基西索米星1.5mg/kg 1次/8小时,7天;B组20人用乙基西索米星4.5mg/kg,1次/日。两组病人均联用甲硝唑,30mg/kg,1次/8小时,7天。术前
Animal experiments show that aminoglycoside antibiotics daily single administration of the same amount of daily injection of 2 to 3 times or continuous intravenous infusion may damage the kidneys and inner ear less. There have been reports that gentamicin is equally effective in treating urinary tract infections with multiple administrations. Ethyl sisomicin ototoxicity than other aminoglycosides. The authors believe systemic treatment with its single-dose regimen appears to be appropriate to test its efficacy and safety. From November 1985 to August 1986, the authors randomized 40 patients with gangrenous and perforated appendicitis surgery. A group of 20 patients received ethyl Sisomicin 1.5mg / kg 1/8 hours, 7 days; Group B 20 people with ethyl sisomicin 4.5mg / kg, 1 / day. Patients in both groups were treated with metronidazole, 30mg / kg, once / 8 hours, 7 days. Preoperative