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本文报告12例原发性甲状旁腺功能亢进症患者经口服甲腈咪胺300mg每日4次治疗,并连续测定血清钙、磷及甲状旁腺激素(PTH),旨在观察本药对PTH的效应。 5例采用周期性治疗(服药2～4周后停药2～4周)。采用手术治疗的另5例术前至少用药8天,手术时PTH水平已正常。当手术前停用口服甲睛咪胺时,均给1次静注,手术时停止治疗。另2例因内科问题或病人不愿手术而延期手术,但仍作观察。全部病人用药后PTH水平回复正常;血清钙下降,但下降程度随给药时间、剂量及途径而变化。当PTH水平回复正常时症状消失,且与钙水平无关。当停用甲腈咪胺时,PTH水平有反跳。
This article reports 12 cases of primary hyperparathyroidism patients treated with oral BCT 300mg 4 times daily, and continuous determination of serum calcium, phosphorus and parathyroid hormone (PTH), to observe the drug on PTH Effect. 5 cases of cyclical treatment (taking 2 to 4 weeks after stopping 2 to 4 weeks). The other 5 cases treated with surgery at least medication for 8 days before surgery, PTH levels have been normal. When the orally administered oral administration of amopentamide before surgery, were given a intravenous injection, surgery to stop treatment. The other 2 cases were delayed because of medical problems or the patient did not want surgery, but still under observation. All patients returned to normal levels of PTH after treatment; serum calcium decreased, but the degree of decline with the administration time, dosage and route changes. Symptoms disappear when PTH levels return to normal, and have nothing to do with calcium levels. PTH levels rebound when deactivation of cimetidine.