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目的:从临床及药代动力学方面,探讨ASP在CNS白血病的药理作用及最佳给药方式。方法:10例ALL患儿分别4次接受了德国小儿白血病协作组多中心协作治疗方案(COALL-97)中的主要药物ASP(每隔4周~ 6周1次静脉注射4×104 U/m2日本协和发酵工业株式会社生产的L-ASP)的联合化疗。检测静脉注射L-ASP前及给药后第1周,第3周,第4周,第5周CSF中的ASN浓度。结果:CSF中ASN浓度均值分别为:给药前1.894 μmol/L,给药后第1周0.056 μmol/L,第3周0.117 μmol/L,第4周0.212 μmol/L,第5周0.897 μmol/L;每例患儿应用L-ASP后CSF中ASN浓度明显降低(P <0.05),同时测定CSF中谷氨酰胺浓度在给药前及给药后均无显著变化。结论:1次注射4×104 U/m2 ASP后能使CSF中ASN浓度降低并持续至第5周后回升。有预防或治疗CNS白血病的作用。
OBJECTIVE: To investigate the pharmacological effects of aspirin on CNS leukemia and its optimal administration mode from clinical and pharmacokinetic aspects. Methods: Ten children with ALL were treated with aspirin (4 × 104 U / m2 intravenous injection once every 4 weeks to 6 weeks) in the multi-center collaborative treatment of the German pediatric leukemia group (COALL-97) Japan’s Kyowa Hakko fermentation Co., Ltd. L-ASP) combination chemotherapy. ASN concentrations in CSF before and after intravenous injection of L-ASP and at week 1, week 3, week 4, and week 5 after administration were determined. Results: The average concentration of ASN in CSF was 1.894 μmol / L before administration, 0.056 μmol / L in the first week after administration, 0.117 μmol / L in the third week, 0.212 μmol / L in the fourth week and 0.897 μmol in the fifth week / L; ASN concentration in CSF was significantly decreased (P <0.05) after L-ASP was applied in each case, while no significant change was observed before and after administration of glutamine in CSF. CONCLUSIONS: After a single injection of 4 × 104 U / m2 ASP, the concentration of ASN in CSF decreased and continued to rise after 5 weeks. Have the effect of preventing or treating CNS leukemia.