用种子溶胀聚合方法 ,合成出了粒度单分散的交联聚甲基丙烯酸甲酯微球 .将微球通过水解 ,使其转化为表面带羧基的树脂 .分别用多糖化合物Dextran和DEAE Dextran对水解树脂表面进行包覆涂层 ,然后用n 丁二醇双环氧丙醚分别进行交联 ,制备出两种表面带高交联多糖覆盖层的树脂 .以两种改性树脂为填料 ,以人血清蛋白为试样 ,用HPLC方法对树脂的亲水性能进行了表征 .研究表明 ,两种改性树脂均有很好的亲水性 ,蛋白质的回收率分别在 97%和 99%以上 ,并有良好的机械强度和化学稳定性 With the method of seed swelling polymerization, the monodispersed crosslinked polymethylmethacrylate microspheres were synthesized and the microspheres were transformed into the carboxyl group-bearing resin by hydrolysis.The microspheres were hydrolyzed with polysaccharide compounds Dextran and DEAE Dextran respectively The surface of the resin coating coating, and then with n Butylene glycol diacetate were cross-linked to prepare two kinds of surface covered with highly cross-linked polysaccharide resin with two modified resin as a filler, The results showed that the two modified resins have good hydrophilicity and the recoveries of protein are above 97% and 99% respectively Have good mechanical strength and chemical stability