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目的比较多西他赛在不同时间点给药后的血药浓度、疗效以及毒性反应的变化,根据其节律变化选择临床最佳给药时间,获得最佳疗效。方法经病理和细胞学证实的60例III、IV期非小细胞肺癌(NSCLC)患者随机分为3组。多西他赛:A组(n=20)在8∶00 am给药,B组(n=20)在2∶00 pm给药,C组(n=20)在8∶00 pm给药;顺铂在多西他赛给药后第2天给予。多西他赛40 mg.m-2,ivgtt,d1,8;顺铂75 mg.m-2,ivgtt,d1,第21天重复。测定给药后1,10,24 h的血药浓度,并评价经化疗2个周期后的疗效和不良反应。结果3组的疗效和血药浓度在统计学上没有显著性差异,但2:00 pm,8:00 pm给药组的不良反应发生率较高。结论多西他赛治疗NSCLC在8∶00 am给药较为安全有效,可增加病例数做进一步的深入研究。
Objective To compare the changes of plasma concentration, efficacy and toxicity after administration of docetaxel at different time points, and select the optimal clinical time for optimal rhythm according to the change of rhythm. Methods Sixty patients with stage III and IV non-small cell lung cancer (NSCLC) confirmed by pathology and cytology were randomly divided into three groups. Docetaxel group A (n = 20) was administered at 8:00 am, group B (n = 20) was administered at 2:00 pm, and group C (n = 20) Cisplatin was given on Day 2 after docetaxel administration. Docetaxel 40 mg.m-2, ivgtt, d1,8; cisplatin 75 mg.m-2, ivgtt, d1, repeated on day 21. The blood concentration of 1, 10, 24 h after the administration was measured, and the curative effect and adverse reaction after 2 cycles of chemotherapy were evaluated. Results There was no statistically significant difference between the three groups in the efficacy and plasma concentration, but the incidence of adverse reactions was higher in the 2:00 pm and 8:00 pm groups. Conclusion Docetaxel treatment of NSCLC at 8:00 am administered more safe and effective, can increase the number of cases for further in-depth study.