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异搏定的主要作用是阻止窦房结、房室结等慢反应细胞的Ca~(2+)内流.降低自律性.延长房室结不应期,有利于消除经房室结折返导致的室上性心动过速.但在预激症候群伴房扑、房颤患者,异搏定可引起心室率加快.其机理为:①异搏定可直接缩短预激旁道(心房与心室间的异常传导途径)的不应期.加速冲动经旁道由心房至心室的前向传导.②抑制房室结的逆向传导.使经由旁道逆向通过房室结的冲动次数减少,间接增加旁道的前向传导.③异
Verapamil is the main role is to prevent the sinoatrial node, atrioventricular node and other slow response Ca ~ (2 +) influx of cells to reduce the self-discipline to extend the atrioventricular node refractory period, is conducive to eliminate the reentry caused by atrioventricular node Of the supraventricular tachycardia.However, in the pre-shock syndrome with atrial flutter, atrial fibrillation patients, verapamil can cause rapid ventricular rate.The mechanism is as follows: Verapamil can directly reduce the pre-excitation bypass (atrial and ventricular Of abnormal conduction path) refractory period.Accelerate the impulse by the bypass from the atrium to the ventricular anterior conduction ② inhibit the reverse conduction of the atrioventricular node.Through the bypass passage through the atrioventricular node impulse reduction, indirectly increase the next Road before the conduction. ③ different