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主要阐述 HBV多聚酶及其逆转录酶区 C区的分子结构 ,YMDD基序及其变异的含义、类型及诱其发生的背景 ,YMDD变异病毒对拉米夫定耐药的分子机制 ,目前用于检测 HBVYMDD变异的分子生物学方法
Mainly elaborates the molecular structure of HBV polymerase and its reverse transcriptase C region, the meaning and type of YMDD motif and its variation, and the background of inducing its occurrence. The molecular mechanism of YMDD mutant virus resistance to lamivudine is currently used in Molecular Biology Method for Detection of HBVYMDD Mutation