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目的:观察雷公藤多甙联合化瘀通络方治疗小儿过敏性紫癜肾炎(HSPN)的临床疗效。方法:将75例患者分为对照组37例和观察组38例。对照组采用强的松为主治疗,观察组采用雷公藤多甙联合化瘀通络方为主辨证治疗。2组疗程均为12周,治疗前后行24 h尿蛋白定量检测,每周行尿红细胞及尿蛋白定性检测。结果:观察组临床综合疗效、尿蛋白及红细胞疗效均优于对照组(P<0.05)。治疗后2组尿红细胞、24 h尿白蛋白水平均较治疗前下降(P<0.01);观察组尿红细胞、24 h尿白蛋白水平均低于对照组,差异有非常显著性意义(P<0.01)。结论:雷公藤多甙联合化瘀通络方治疗小儿HSPN临床疗效显著,值得临床推广使用。
Objective: To observe the clinical effect of Tripterygium wilfordii polyglycoside combined with Huayu Tongluo Recipe in treating children with Henoch-Schonlein purpura nephritis (HSPN). Methods: Seventy-five patients were divided into control group (37 cases) and observation group (38 cases). Control group prednisone-based treatment, the observation group using Tripterygium glycosides combined with Huayu Tongluo prescription-based treatment. The two groups of treatment were 12 weeks, 24 hours before and after treatment of urinary protein quantitative detection of urinary red blood cells per week and urine protein qualitative detection. Results: The clinical efficacy, urinary protein and erythrocyte efficacy in the observation group were better than those in the control group (P <0.05). After treatment, urinary erythrocytes in two groups and urine albumin in 24 hours decreased compared with those before treatment (P <0.01). The level of urinary erythrocytes and 24-hour urinary albumin in the observation group were significantly lower than those in the control group (P < 0.01). Conclusion: Tripterygium glycosides combined with Huayu Tongluo Recipe in treating children with HSPN has a significant clinical effect and is worthy of clinical promotion.