氯丙嗪致癫痫发作早有报导。但是,其他神经阻断剂是否可致癫痫发作仍有争论。为了进一步了解这一问题,作者用最近发展的海马切片技术,研究了各种药物对海马发出的波峰活动的影响程度,从而提出了一些值得注意的看法。方法:突然杀死雄性豚鼠,切下其脑取出海马。冰冻后切成400微米厚的薄片,置于含多种化合物的渗透室中,保持室温37℃,培养1～1.5小时。再用较多的氯化钾及3000 Chlorpromazine-induced seizures have long been reported. However, whether other neuroleptic agents can cause seizures remains controversial. To further understand this issue, the authors used the recent development of hippocampal slice technology to study the degree of influence of various drugs on peak activity in the hippocampus, and made some noteworthy observations. Methods: Male guinea pigs were killed suddenly and their brains removed. Frozen and cut into 400-micron thick slices, placed in a variety of compounds containing the permeation chamber, to maintain the room temperature 37 ℃, incubated for 1 to 1.5 hours. Reuse more potassium chloride and 3000