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目的了解异烟肼预防性治疗对HIV/AIDS患者结核感染的预防性效果。方法对湖北省随州市2006年符合预防性治疗标准的HIV/AIDS患者进行9个月的异烟肼预防性治疗,随访观察其治疗结果并与2005年的相关资料进行对比分析。结果对HIV总人群来说,异烟肼预防性治疗对预防结核的发生(P=0.18)及病例的死亡无显著影响(P=0.06),但对PPD(+)的HIV患者的死亡(P=0.03)与结核发病有明显的保护作用(P=0.00),且不良反应轻微。结论 PPD(+)的HIV患者实施9个月的异烟肼预防性治疗是切实可行的,具有明显的保护效果。
Objective To investigate the preventive effect of isoniazid prophylaxis on tuberculosis in HIV / AIDS patients. Methods Nine months of prophylactic isoniazid treatment of HIV / AIDS patients who met the standard of prophylactic treatment in Suizhou, Hubei Province in 2006 were followed up to observe the treatment results and compared with the relevant data in 2005. Results Preventive treatment with isoniazid had no significant effect on the prevention of tuberculosis (P = 0.18) and case death (P = 0.06) for the general population of HIV, but for patients with PPD (+) death (P = 0.03) and tuberculosis have a significant protective effect (P = 0.00), and mild adverse reactions. Conclusion It is practicable to carry out prophylactic isoniazid treatment for 9 months in HIV patients with PPD (+), with obvious protective effect.