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以穿心莲内酯、无水吡啶、琥珀酸酐、无水亚硫酸钠,在真空条件下,加热回流反应生成炎琥宁(脱水穿心莲内酯二琥珀酸半酯钾钠盐)的重要中间体脱水穿心莲内酯二琥珀酸半酯,在洗涤时使用酸性水溶液,总收率89.7%,含量91.3%,并对生产中关键控制点加以阐述。操作工序简便,生产成本大大降低,收率高。
To the andrographolide, anhydrous pyridine, succinic anhydride, anhydrous sodium sulfite, under vacuum, heating reflux reaction to form an important intermediate of mesylate (dehydroandrographolide disuccinic acid half-ester potassium-sodium salt) dehydration andrographolide Disuccinic acid half ester, acidic aqueous solution used in washing, the total yield of 89.7%, content of 91.3%, and the production of key control points are described. The operation procedure is simple, the production cost is greatly reduced and the yield is high.