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由国际糖尿病联盟 (IDF)召集的本次研讨会是为了考察有关糖耐量低减 (IGT)和空腹血糖受损 (IFG)相关的糖尿病和心血管疾病 (CVD)风险的最新文献 ,力图回答三个问题 :(1 )目前的IGT和IFG的定义是否合适 ;(2 )IFG和IGT是危险因子 (riskfactor)、危险标志 (riskmarker)还是疾病 (disease) ;(3)对 :IFG和IGT人群应该采取怎样的干预措施 (如果有的话 ) ?①引起空腹血糖 (FPG)和口服葡萄糖耐量试验(OGTT) 2h血糖 (2hPG)升高的因素并不相同 ,肝脏葡萄糖输出增加和早期胰岛素释放缺陷是前者的特点 ,而外周胰岛素抵抗是后者的显著特征。因此 ,IFG和IGT之间的一致性是有限的。迄今所有的患病率调查发现 ,只有不到一半的IFG人群有IGT ,更少的IGT人群 (2 0 %～ 30 % )有IFG。②大多数的人群研究表明 ,IGT的患病率远高于IFG ,二者的临床表现和性别分布也有差异。IFG在男性更为常见 ,IGT在女性稍微增多。IFG的患病率倾向在中年达到高峰 ,而IGT的患病率逐渐增加直到老龄。③IFG和IGT都与发生糖尿病的风险显著增加有关 ,而最大的风险在于同时具有IFG和IGT的人群。由于在多数人群IGT比IFG更常见 ,所以对于筛查糖尿病高危人群 ,IGT的敏感性较高 (特异性稍差 )。在多数人群 ,60 %的糖尿病人大约 5年前已有IGT或IFG ,另外 40
This symposium, convened by the International Diabetes Federation (IDF), is designed to examine recent literature on the risk of diabetes and cardiovascular disease (CVD) associated with impaired glucose tolerance (IGT) and impaired fasting glucose (IFG) (1) Is the current definition of IGT and IFG appropriate; (2) Is IFG and IGT risk factors, risk markers or disease; (3) For IFG and IGT populations should What interventions, if any, were taken? ① The factors that cause elevated 2h blood glucose (2hPG) in fasting blood glucose (FPG) and oral glucose tolerance test (OGTT) are not the same. Increased hepatic glucose output and early insulin release defects are The former characteristics, and peripheral insulin resistance is the salient features of the latter. Therefore, the consistency between IFG and IGT is limited. All prevalence studies to date have found that less than half of IFG populations have IGT, and fewer IGT populations (20% to 30%) have IFG. ② Most population studies show that the prevalence of IGT is much higher than that of IFG, and the clinical manifestations and gender distribution of the two are also different. IFG is more common in males and IGT is slightly more females. The prevalence of IFG tends to peak in middle age, while the prevalence of IGT gradually increases until age. ③ Both IFG and IGT are associated with a marked increase in the risk of developing diabetes, with the greatest risk being in people with both IFG and IGT. Because IGT is more common in most populations than IFG, IGT is more sensitive (less specific) for screening people at high risk for diabetes. In the majority of people, 60% of people with diabetes have IGT or IFG about 5 years ago and another 40%