药物遗传学是近廿年来由药理学、生物化学与遗传学等学科相互渗透而融合出现的一门新兴边缘学科。很早以来人们就观察到机体对药物的异常反应,并笼统称之为特异质。例如服用抗疟药伯氨喹可引起溶血性贫血。后来发现具有这种“特异质”的人乃是由于遗传缺陷,红细胞内缺乏6-磷酸葡萄糖脱氢酶(G-6PD)的缘故,而服用非那西汀引起高铁血红蛋白 Pharmacogenetics is an emerging edge subject that has emerged from the mutual penetration of disciplines such as pharmacology, biochemistry and genetics in recent twenty years. People have long been aware of the abnormal response of the body to drugs, and generally referred to as specific. For example, taking primaquine antimalarial drugs can cause hemolytic anemia. Later found that with this “specific” people because of genetic defects, the lack of red blood cells in the 6-phosphoglucose dehydrogenase (G-6PD) sake, and taking phenacetin cause methemoglobin