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天然药物有效成分中作用缓和的多糖类、氨基酸及有机酸近年来已逐渐引起国内外的注意。目前国内对多糖类免疫活性物质研究较多,对有机酸的研究仅仅是开始。已发现某些抗蛇毒及镇痛、消炎、止痛中草药的有效成分为丁二酸和反丁烯二酸,它们可对抗多种惊厥,并有多方面的中枢抑制作用,至于顺丁烯二酸有无类似作用未见报道。丁二酸和反丁烯二酸的抗惊厥作用与中枢神经系统主要的抑制性递质γ-氨基丁酸(GABA)
Active substances in natural medicines to ease the role of polysaccharides, amino acids and organic acids in recent years has gradually attracted domestic and international attention. At present, there are many researches on polysaccharide immunocompetent substances in China, and the study of organic acids is just the beginning. Some anti-snake venom and analgesic, anti-inflammatory and analgesic active ingredients of Chinese herbal medicine have been found to be succinate and fumarate. They are effective against a variety of convulsions and have various central inhibitory effects. As for maleic acid No similar effect has not been reported. The anticonvulsant effects of succinic acid and fumaric acid are similar to those of the central inhibitory neurotransmitter γ-aminobutyric acid (GABA)