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目的:比较16周自发性高血压大鼠(SHR)和对照组Wistar-Kyoto(WKY)大鼠中枢神经系统中与血压调节有关的核团内阿片受体密度的变化.方法:用放射自显影方法,运用氚标依托啡作配基检测阿片受体的分布. 结果:在海马(P<0.01)、中央灰质、孤束核、胸髓(P<0.05)几处,SHR阿片受体密度较WKY大鼠低;而在杏仁核(P<0.01)、僵核(P<0.05)和下丘脑核群包括弓状核(P<0.01),SHR却有较高的阿片受体密度. 结论:不同分布的阿片受体与自发性高血压大鼠的血压有关.
OBJECTIVE: To compare the change of density of endoplasmic reticulum receptors involved in blood pressure regulation in the central nervous system of 16-week-old spontaneously hypertensive rats (SHR) and control Wistar-Kyoto (WKY) rats.Methods: Autoradiogram METHODS: The distribution of opioid receptor was detected by tritium-labeled etoposide.Results: The density of SHR opioid receptors in hippocampus (P <0.01), central gray matter, solitary nucleus and thoracic marrow (P <0.05) WKY rats were lower than those in the control group (P <0.01), while nucleus accumbens (P <0.05) and arcuate nucleus (P <0.01) Different distribution of opioid receptors and spontaneously hypertensive rats blood pressure.