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新抗菌素——创新霉素是济南游动放线菌的代谢产物。 通过形态学及培养特征研究确认该菌为一新种,并已制成结晶品,本文报道该抗菌素的测定、发酵和提取方法,以及该抗菌素的紫外吸收光谱、红外吸收光谱、核磁共振谱、质谱和比旋光度。它的分子式为C_(12)H_(11)NO_2S,分子结构和全合成研究均已完成,从分子结构看,它是一个新型的抗菌素,体外试验,创新霉素对部分革兰氏阴性细菌和部分革兰氏阳性细菌有抑制作用,体内试验,它对痢疾杆菌和大肠杆菌感染的小鼠都有保护作用,它的毒性较低,对小鼠的LD_(50)为600毫克/公斤(静脉)和1770毫克/公斤(口服),临床试用对大肠杆菌引起的败血症,泌尿系感染,胆道感染等均有一定疗效。
The new antibiotic, neomycin, is the metabolite of the actinomycetes from the south of Jinan. According to the morphological and culturing characteristics, it was confirmed that the strain is a new species and has been made into a crystalline product. This article reports the determination, fermentation and extraction methods of the antibiotic, as well as the ultraviolet absorption spectrum, infrared absorption spectrum, nuclear magnetic resonance spectrum, Mass spectrometry and specific rotation. Its molecular formula C_ (12) H_ (11) NO_2S, molecular structure and total synthesis of the study have been completed, from the molecular structure, it is a new type of antibiotic, in vitro experiments, innovative to some of gram Gram-negative bacteria and Some Gram-positive bacteria have an inhibitory effect in vivo and have protective effects on both Shigella and Escherichia coli-infected mice, and their toxicity is relatively low. LD 50 for mice is 600 mg / kg (iv ) And 1770 mg / kg (oral), clinical trials of E. coli-induced sepsis, urinary tract infections, biliary tract infections have a certain effect.