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应用愈创木酚法对６７例术前服０～４０ｍｇ／ｄ他巴唑（ＭＭＩ）的Ｇｒａｖｅｓ病甲状腺过氧化物酶（ＴＰＯ）活性进行测定。ＭＭＩ为０～１５ｍｇ／ｄ时，随剂量增加ＴＰＯ活性渐降低；当到１５ｍｇ／ｄ时，ＴＰＯ活性基本降至最低，即使再增加剂量，ＴＰＯ活性未再继续降低。ＭＭＩ顿服与分服相同剂量时ＴＰＯ活性相同，对ＴＰＯ抑制作用至少可持续２４小时。因此ＭＭＩＩ５ｍｇ／ｄ是治疗甲亢的合适剂量，每日１次顿服的疗法是合理而有效的。
The activity of thyroid peroxidase (TPO) in Graves’ disease of 67 patients preoperatively administered 0 ~ 40mg / d methimazole (MMI) was determined by guaiacol method. When MMI was 0 ~ 15mg / d, the activity of TPO gradually decreased with the increase of dosage. When the dosage was 15mg / d, the activity of TPO was reduced to the lowest, and even if the dosage was increased, the activity of TPO did not decrease further. The same dose of MTP suits and sub-doses of the same TPO activity, inhibition of TPO can last at least 24 hours. Therefore MMII5mg / d is the appropriate dose for the treatment of hyperthyroidism, Dayton clothing daily therapy is reasonable and effective.