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葆妇欣颗粒剂具有益气补血,止血调经的作用,对于带铜IUD出血、腰腹疼痛等副反应具有良好疗效。为探讨其作用机理,我们对其进行了一系列止血、镇痛的实验研究。其中包括对家兔在体子宫收缩的影响;对正常小鼠出、凝血时间的影响;对肝素造模小鼠出凝血时间的影响;对动情期大鼠血清纤维蛋白降解产物(FDP)及6-酮-前列腺素F_(1α)(6-K-PGF_(1α))、子宫6-K-PGF_(1α)的影响;对小鼠热板法镇痛实验的影响;对小鼠醋酸扭体法镇痛实验的影响。所有实验结果表明葆妇欣颗粒剂具有良好的止血、镇痛作用,为其临床验证提供了药理学依据。
Baofu Xin granules with the role of Qi and blood, stop bleeding and menstruation role, with copper IUD bleeding, waist and abdominal pain and other side effects have a good effect. To explore its mechanism of action, we conducted a series of experimental studies on hemostasis and analgesia. Including the rabbit in vivo uterine contraction; out of normal mice clotting time; coagulation of heparin-induced mouse clotting time; estrus rat serum fibrin degradation products (FDP) and 6 Keto-prostaglandin F 1α (6-K-PGF_ (1α)) and uterus 6-K-PGF_ (1α) on the analgesic effect of hot plate method in mice. Effect of Analgesic and Analgesic Experiments. All experimental results show that Baofu Xin granules have good hemostatic and analgesic effects, providing a pharmacological basis for clinical validation.