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目的观察雷公藤多苷片联合甲氨蝶呤片治疗类风湿性关节炎的临床疗效及其安全性。方法选取2015年7月-2016年7月收治的类风湿性关节炎患者50例,随机分为观察组和对照组,每组25例。对照组采用甲氨蝶呤片10mg,每周1次。观察组在对照组的基础上联合雷公藤多苷片20mg/次,3次/d。持续服药3个月。观察患者治疗前后的关节肿胀数、关节压痛个数、红细胞沉降率以及C反应蛋白含量。结果服用雷公藤多苷片联合甲氨蝶呤片治疗3个月后,患者的肿胀数及关节压痛个数较治疗前显著减少(P<0.01),红细胞沉降率以及C反应蛋白含量均显著下降(P<0.01)。结论雷公藤多苷片联合甲氨蝶呤片治疗类风湿性关节炎的临床效果较好,不良反应发生率较低,为类风湿关节炎可选方案。
Objective To observe the clinical efficacy and safety of Tripterygium wilfordii glycosides combined with methotrexate tablets in the treatment of rheumatoid arthritis. Methods Fifty patients with rheumatoid arthritis who were admitted from July 2015 to July 2016 were randomly divided into observation group and control group, with 25 cases in each group. Control group with methotrexate tablets 10mg, once a week. Observation group in the control group based on the combination of Tripterygium glycosides tablets 20mg / times, 3 times / d. Continued medication for 3 months. The number of joint swelling, joint tenderness, erythrocyte sedimentation rate and C-reactive protein content before and after treatment were observed. Results Three months after treatment with tripterygium glycosides and methotrexate, the number of swelling and joint tenderness were significantly decreased (P <0.01), and erythrocyte sedimentation rate and C-reactive protein content were significantly decreased (P <0.01). Conclusion Tripterygium glycosides tablets combined with methotrexate tablets in the treatment of rheumatoid arthritis, the clinical effect is good, the incidence of adverse reactions is low, as an alternative to rheumatoid arthritis.