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[目的]探讨凋亡抑制蛋白Livin在宫颈上皮内瘤变(CIN)和宫颈癌中的表达及意义。[方法]采用免疫组织化学SP法检测81例宫颈癌、74例CIN和20例正常宫颈组织中Livin的表达情况。[结果]Livin在正常宫颈组织中不表达,在CIN和宫颈癌中表达上调,阳性率分别为31.08%(23/74)和67.90%(55/81)。Livin在CINⅢ组织中的阳性率高于CINⅠ～Ⅱ。Livin表达与肿瘤临床分期、分化程度及淋巴结转移有关(P<0.05),而与病理类型、肿块生长类型无相关性(P>0.05)。[结论]Livin过表达可能与CIN和宫颈癌的发生发展有关,提示肿瘤的恶性程度及不良预后。
[Objective] To investigate the expression and significance of Livin, an inhibitor of apoptosis, in cervical intraepithelial neoplasia (CIN) and cervical cancer. [Method] Immunohistochemical SP method was used to detect the expression of Livin in 81 cases of cervical cancer, 74 cases of CIN and 20 cases of normal cervical tissue. [Results] Livin was not expressed in normal cervical tissue and up-regulated in CIN and cervical cancer, the positive rates were 31.08% (23/74) and 67.90% (55/81), respectively. The positive rate of Livin in CIN Ⅲ tissues was higher than that in CIN Ⅰ ~ Ⅱ. The expression of Livin was correlated with the clinical stage, differentiation degree and lymph node metastasis (P <0.05), but not with the pathological type and tumor growth type (P> 0.05). [Conclusion] The overexpression of Livin may be related to the occurrence and development of cervical intraepithelial neoplasia and cervical intraepithelial neoplasia, suggesting the malignant degree and poor prognosis of the tumor.