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目的探讨坦克舱室有害因素长期暴露对乘员血清过氧化脂质水平及抗氧化能力的影响。方法选取169名职业性坦克乘员为观察组,并以1∶1配对在同一部队选取基本情况相似的169名不接触任何毒物的健康战士作为对照组。以化学比色法测定2组人员血清脂质过氧化产物丙二醛(MDA)含量及超氧化物歧化酶(SOD)、谷胱甘肽过氧化物酶(GSH-Px)、过氧化氢酶(CAT)、髓过氧化物酶(MPO)的活性。结果观察组血清SOD、GSH-Px活性显著低于对照组(P<0.05,P<0.01),MPO活性显著高于对照组(P<0.01)。与同年龄段的对照组相比,>20～25岁年龄段组MDA含量及MPO活性显著升高(P<0.05,P<0.01),SOD、GSH-Px活性显著降低(P<0.05)。与同军龄段的对照组相比,观察组≤2年军龄段组SOD活性显著降低(P<0.05),MPO活性显著升高(P<0.01);观察组>2～5年军龄段组MDA含量和MPO活性显著升高(P<0.01)。与对照组相比,观察组不同坦克作业岗位中炮长血清MPO活性显著升高(P<0.01),驾驶员血清SOD及GSH-Px活性显著降低(P<0.05,P<0.01),MPO活性显著升高(P<0.01)。结论长期暴露于舱室有害因素的坦克乘员受到的氧化损伤加重,同时机体的抗氧化能力降低;不同年龄段、军龄段及作业岗位的坦克乘员中,分别以>20～25岁、>2～5年军龄段及坦克驾驶员受到的氧化损伤最严重。
Objective To investigate the effects of long-term exposure of harmful factors in tank compartment on serum lipid peroxidation and antioxidant capacity in passenger compartment. Methods A total of 169 occupational tank crew members were selected as observation group and 169 healthy soldiers who did not contact with any poisonous substance were selected as the control group in the same unit with a 1: 1 pair. The levels of serum malondialdehyde (MDA), superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), catalase (CAT), myeloperoxidase (MPO) activity. Results The activities of serum SOD and GSH-Px in the observation group were significantly lower than those in the control group (P <0.05, P <0.01). The activity of MPO in the observation group was significantly higher than that in the control group (P <0.01). Compared with the same age group, the content of MDA and the activity of MPO in> 20 ~ 25 age group were significantly increased (P <0.05, P <0.01), and the activities of SOD and GSH-Px were significantly decreased (P <0.05). Compared with the control group of the same age group, the activity of SOD and the activity of MPO in the observation group were significantly lower than those in the age group of ≤2 years (P <0.01) Content and MPO activity increased significantly (P <0.01). Compared with the control group, the serum MPO activity of the gunners in the observation group was significantly increased (P <0.01), the activities of serum SOD and GSH-Px in the pilots were significantly decreased (P <0.05, P <0.01), MPO activity Significantly increased (P <0.01). Conclusion The tank crew exposed to harmful factors in cabin for a long time suffered from oxidative damage and the antioxidant capacity of the tank was reduced. Among the crew members of military age group and working position, the crew members aged> 20-25 years,> 2-5 Year of age and tank drivers suffered the most serious oxidative damage.