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应用免疫组织化学方法对５８例子宫颈鳞状上皮细胞癌及５例宫颈上皮内瘤样病变标本的Ｐ１６基因表达进行研究，取８例正常子宫颈组织作对照。结果显示：Ｐ１６基因免疫反应产物主要定位于细胞浆内，阳性细胞在组织中的分布呈巢状、灶性或分散性。Ｐ１６基因的阳性表达率在宫颈鳞癌、宫颈上皮内瘤样病变及正常宫颈组织中分别为４３１％、４０％和１２５％。肿瘤病理分级越低，临床分期越晚，阳性表达率越低，差异有显著性（Ｐ＜００５）。提示：Ｐ１６基因的异常表达在子宫颈鳞癌的发生、发展过程中起重要作用
Immunohistochemistry was used to study the expression of P16 gene in 58 cases of cervical squamous cell carcinoma and 5 cases of cervical intraepithelial neoplasia. Eight normal cervical tissues were used as controls. The results showed that the P16 gene immunoreaction product was mainly located in the cytoplasm, and the distribution of positive cells in the tissue was nested, focal or dispersive. The positive rate of P16 gene expression in cervical squamous cell carcinoma, cervical intraepithelial neoplasia, and normal cervical tissue was 43.1%, 40%, and 12.5%, respectively. The lower the tumor pathological grade, the later the clinical stage, the lower the positive expression rate, and the difference was significant (P < 0.05). Tip: The abnormal expression of P16 gene plays an important role in the occurrence and development of cervical squamous cell carcinoma