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目的了解上海市部份地区健康人群水痘-带状疱疹病毒(VZV)自然感染状况。方法采集0~50岁健康人群血清标本921人份,用酶联免疫吸附试验测定抗体水平。结果人群血清中抗VZV-IgG总阳性率为42.78%,几何平均滴度(GMT)为1∶206.69。以0~2岁最低,阳性率为14.52%~18.33%,GMT为1∶45.36~1∶67.97。以后随年龄增长而逐步升高,3、4、5、6、7、8~9、10~141、5~19、20~29、30~39、40~50岁阳性率分别为21.37%、23.81%、27.91%、45.95%、29.63%、91.18%、88.57%、100.00%、97.14%、96.67%、100.00%。7岁以前感染率为45.9%。结论以上数据对应用水痘疫苗免疫预防策略及接种对象提供了科学依据。
Objective To understand the natural infection status of varicella-zoster virus (VZV) in healthy population in some areas of Shanghai. Methods Nine hundred and seventy-one serum samples from 0-50-year-old healthy people were collected and their antibody levels were determined by enzyme-linked immunosorbent assay. Results The total positive rate of anti-VZV-IgG in serum was 42.78% and the geometric mean titer (GMT) was 1:206.69. The lowest was 0-2 years old, the positive rate was 14.52% ~ 18.33%, GMT was 1:45.36 ~ 1:67.97. Later with the increase of age and gradually increased, 3,4,5,6,7,8 to 9,10 to 141,5 to 19,20 to 29,30 to 39,40 to 50-year-old positive rates were 21.37%, respectively, 23.81%, 27.91%, 45.95%, 29.63%, 91.18%, 88.57%, 100.00%, 97.14%, 96.67%, 100.00%. The infection rate before the age of 7 was 45.9%. Conclusion The above data provide a scientific basis for the immunization prevention strategy and vaccination target of chickenpox vaccine.