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急性肝内胆汁郁滞症(下称急胆郁)与梗阻性黄疸的鉴别有时仍很困难,治疗方法亦未臻善。本文综述近年有关的资料。急胆郁的病因:(1) 药物,多见于氯丙嗪、同化激素、利福平、红霉素、呋喃坦啶及硫唑嘌呤等;个别见于青霉素,氯霉素、安定、PAS、D860及 APC 等,系过敏或直接毒性所致,(2) 酒精,出现在酗酒后;(3) 肝炎病毒,2～5%各型急性病毒性肝炎呈胆郁型;10～20%慢性活动性肝炎出现胆郁,有者呈急进型,肝组织学常为亚急性坏死,预后严重,(4) 革兰氏阴性菌在胆系或泌尿系感染。有时手术引起腹腔感染,于
Acute intrahepatic cholestasis (hereinafter referred to as emergency bile depression) and the identification of obstructive jaundice is sometimes still difficult, the treatment is not satisfactory. This article summarizes the relevant information in recent years. Etiology of acute and severe depression: (1) drugs, more common in chlorpromazine, assimilation hormones, rifampicin, erythromycin, furadantin and azathioprine, etc .; some found in penicillin, chloramphenicol, stability, PAS, D860 And APC, caused by allergies or direct toxicity, (2) alcohol, after alcoholism; (3) hepatitis virus, 2 ~ 5% of various types of acute viral hepatitis was gallstones; 10 ~ 20% of chronic activity Hepatitis appeared gallbladder, some were radical into the liver histology often subacute necrosis, the prognosis is serious, (4) Gram-negative bacteria in the biliary or urinary tract infections. Sometimes surgery caused by abdominal infection, in