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目的观察急性冠脉综合征(ACS)患者入院时和1周时血小板聚集率、血小板CD62p、尿11-脱氢-TXB2与炎性因子高敏C-反应蛋白(Hs-CRP)的水平。方法选取年龄43~90岁、符合ACS诊断标准如不稳定心绞痛或急性心肌梗死(心梗)的患者95例,入院前每日口服阿司匹林0.1g,至少服用1周以上。测定患者入院时和1周时的血小板聚集率、CD62p、Hs-CRP、尿11-脱氢-TXB2的水平,同时随访6个月时临床终点事件的发生。结果AMI组和UAP组患者ADP、AA诱导的血小板聚集率、CD62p、Hs-CRP和尿11-脱氢-血栓素TXB2均显著高于对照组。除了1周时AMI组AA诱导的血小板聚集率与对照组AA诱导的血小板聚集率比较差异有显著性,1周时UAP组、AMI组和UAP组各指标与对照组比较均无差异。结论炎性因子和血小板的活化可能都是影响ACS患者病情发展以及预后的重要因素。尿11-DH-TXB2、Hs-CRP为影响临床终点事件的因素。
Objective To observe the platelet aggregation rate, platelet CD62p, urinary 11-dehydro-TXB2 and Hs-CRP levels in patients with acute coronary syndrome (ACS) on admission and at 1 week. Methods Ninety-five patients aged 43-90 years who met ACS diagnostic criteria such as unstable angina or acute myocardial infarction (MI) were given 0.1g aspirin daily before admission, taking at least one week. The incidence of platelet aggregation, CD62p, Hs-CRP and urinary 11-dehydro-TXB2 levels at admission and at 1 week were measured. The clinical endpoint was followed up for 6 months. Results ADP, AA induced platelet aggregation rate, CD62p, Hs-CRP and urinary 11-dehydro-thromboxane TXB2 in AMI group and UAP group were significantly higher than those in control group. Except for 1 week, there was a significant difference in AA-induced platelet aggregation rate between AA group and AA-induced platelet aggregation rate. There was no difference between UAP group, AMI group and UAP group at 1 week compared with control group. Conclusions Inflammatory factors and platelet activation may all be important factors that influence the progression of disease and the prognosis of patients with ACS. Urine 11-DH-TXB2, Hs-CRP are the factors affecting the clinical end point.