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目的：评价血、尿β２微球蛋白（β２Ｍ）对早期发现前列腺增生症（ＢＰＨ）患者轻度肾功能损害的作用。方法：测定了１１２例ＢＰＨ患者的血β２Ｍ、尿β２Ｍ、血肌酐（Ｃｒ）水平、膀胱残余尿量（ＰＶＲ）及尿流率，并以６５例健康人作为对照。结果：重度梗阻组患者尿中β２Ｍ明显高于对照组（Ｐ＜０．０５），且与其膀胱残余尿量和最大尿流率（Ｑｍａｘ）有显著相关性（Ｐ＜０．０２５），而血β２Ｍ和Ｃｒ值则与对照组无明显差别（Ｐ＞０．０５）；轻度梗阻组患者血β２Ｍ、尿β２Ｍ、血Ｃｒ值与对照组无明显差别（Ｐ＞０．０５）。结论：检测β２Ｍ可早期发现ＢＰＨ患者的轻度肾功能障碍，且尿β２Ｍ较血β２Ｍ、Ｃｒ更灵敏
Objective: To evaluate the effect of blood and urine β2-microglobulin (β2M) on mild renal damage in patients with benign prostatic hyperplasia (BPH). Methods: Blood β2M, urinary β2M, serum creatinine (Cr) level, residual bladder volume (PVR) and urinary flow rate were measured in 112 patients with BPH. Totally 65 healthy people were used as control. Results: The urinary β2M in severe obstruction group was significantly higher than that in control group (P <0.05), and was significantly correlated with residual urine volume and maximum flow rate (Qmax) (P <0.025) β2M and Cr had no significant difference with those of the control group (P> 0.05). There was no significant difference in blood β2M, urine β2M and blood Cr between the mild obstruction group and the control group (P> 0.05). Conclusion: The detection of β2M early detection of mild renal dysfunction in patients with BPH, and urine β2M than blood β2M, Cr more sensitive