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强直性脊柱炎(AS)多发于青年男性,中国人群患病率约为0.3%,病因和发病机理尚不完全清楚[1],随着HLA基因分型性技术的成熟和发展,从亚型水平探讨AS的发病机制已成为可能,迄今已检出25个HLA-B27等位基因(亚型)。可编码23种蛋白质(B2701-B2723)[2]。目前的研究显示,不同亚型可表现
Ankylosing spondylitis (AS) occurs frequently in young men. The prevalence in Chinese population is about 0.3%. The etiology and pathogenesis of this disease are not fully understood [1]. With the maturation and development of HLA genotyping technologies, It has become possible to explore the pathogenesis of AS at a level that has so far identified 25 HLA-B27 alleles (subtypes). Can encode 23 kinds of proteins (B2701-B2723) [2]. The current study shows that different subtypes can be demonstrated