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目的:观察泻黄散加减治疗乳腺癌化疗期口腔溃疡的临床疗效。方法:将68例乳腺癌化疗期口腔溃疡患者随机分为治疗组和对照组各34例。对照组给予临床常规治疗,治疗组在此基础上,给予泻黄散加减口服治疗,共治疗7 d。比较两组治疗前后基本临床指标、口腔溃疡面积、疼痛评分、口腔溃疡临床分度及免疫功能指标的变化情况,评估临床疗效,并统计治疗期间不良反应的发生情况。结果:治疗组治疗后普食恢复时间和口腔溃疡改善时间均明显短于对照组(P<0.05),总有效率明显高于对照组(P<0.05);两组治疗后口腔溃疡面积及疼痛评分均明显降低(P<0.05),且治疗组治疗后的改善状况均明显优于对照组(P<0.05);治疗后,两组口腔溃疡临床分度均明显改善(P<0.05),且治疗组的改善状况明显优于对照组(P<0.05);治疗后,治疗组CD3+、CD4+、CD4+/CD8+及NK均显著升高(P<0.05),CD8+显著降低(P<0.05),对照组治疗前后免疫指标差异无统计学意义(P>0.05);两组治疗期间均未出现严重不良反应(P>0.05)。结论:泻黄散加减治疗乳腺癌化疗期口腔溃疡,能够显著改善口腔溃疡临床分度、溃疡面积及溃疡疼痛,疗效确切。
Objective: To observe the clinical curative effect of Xiehuang powder on the treatment of oral ulcer in chemotherapy of breast cancer. Methods: A total of 68 patients with oral ulcer during chemotherapy were randomly divided into treatment group (34 cases) and control group (34 cases). The control group was given routine clinical treatment. On the basis of this, the treatment group was treated with oral administration of Xiehuang Powder, and oral treatment was given for 7 days. The changes of basic clinical indexes, area of oral ulcer, pain score, clinical index of oral ulcer and immune function indexes before and after treatment were compared between two groups to evaluate the clinical effect and to count the incidence of adverse reactions during the treatment. Results: After treatment, the recovery time of general diet and oral ulcer were significantly shorter in treatment group than in control group (P <0.05), and the total effective rate was significantly higher than that in control group (P <0.05). After treatment, the area and pain of oral ulcer (P <0.05), and the improvement of the treatment group was better than that of the control group (P <0.05). After treatment, the clinical scores of oral ulcer in both groups were significantly improved (P <0.05) After treatment, the levels of CD3 +, CD4 +, CD4 + / CD8 + and NK in the treatment group were significantly increased (P <0.05), while the levels of CD8 + in the treatment group were significantly decreased (P <0.05) There was no significant difference in immune index before and after treatment (P> 0.05). No serious adverse reactions occurred in both groups during the treatment (P> 0.05). Conclusion: The addition and subtraction of Xiehuang powder for the treatment of oral ulcer during the chemotherapy of breast cancer can significantly improve the clinical index, ulcer area and ulcer pain of oral ulcer, and the curative effect is definite.