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目的:研究水苏碱在家兔体内的药物动力学。方法:采用HPLC法测定从家兔耳静脉注射盐酸水苏碱溶液后不同时间的血浓度。用3P97药动学程序对血药浓度-时间数据进行拟合。结果:主要药动学参数为AUC=1712.50min·μg·ml~(-1),Vc=11.80L·kg~(-1),t_(1/2α)=32.46(min),t_(1/2β)=189.61min,K_(21)=3.97×10~3min~(-1),K10=1.97×10~2min~(-1),K_(12)=1.36×10min~(-1),CLs=0.23L·kg~1·min~(-1)。结论:水苏碱在家兔体内呈二室模型。
Objective: To study the pharmacokinetics of stachydrine in rabbits. Methods: The plasma concentrations of stachydrine hydrochloride from rabbit ear vein were measured by HPLC at different times after injection. The 3P97 pharmacokinetics program was used to fit the plasma concentration-time data. Results: The main pharmacokinetic parameters were AUC = 1712.50min · μg · ml -1, Vc = 11.80L · kg -1, t 1/2½ = 32.46 min, t 1 / 2β = 189.61min, K 21 = 3.97 × 10-3min -1, K 10 = 1.97 × 10-2min -1, K 12 = 1.36 × 10min -1, CLs = 0.23L · kg ~ 1 · min ~ (-1). Conclusion: Stachydine in rabbits showed a two-compartment model.