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目的：探讨醒脑静注射液联合盐酸纳洛酮治疗急性酒精中毒患者的疗效。方法连续纳入90例急诊就诊的急性酒精中毒的患者，分为治疗组和对照组各45例。对照组给予常规治疗及纳洛酮，治疗组在对照组的基础上加用醒脑静注射液，比较两组患者开始清醒时间及完全恢复时间是否有差异。结果90例急性酒精中毒的患者经治疗均完全恢复。治疗组和对照组开始清醒时间分别为（2.1±2.7）h和（3.8±2.5）h，两组比较差异有统计学意义（P＜0.05）。治疗组和对照组完全恢复的时间分别为（4.7±3.8）h和（6.2±4.3）h，两组比较差异有统计学意义（P＜0.05）。结论对于急性酒精中毒的患者，给予纳洛酮联合醒脑静注射液疗效好于单用纳洛酮，建议治疗急性酒精中毒时应用醒脑静注射液。“,”Objective To investigate the clinical efifcacy of naloxone combined with Xingnaojing injection in the treatment of acute alcoholism.MethodsA total of 90 consecutive cases with acute alcoholism in the emergency department of our hospital were divided into treatment group and control group, 45 cases in each group. On the basis of the conventional treatment and naloxone in control group, Xingnaojing injection was added in treatment group. Compared the difference in waking time and complete recovery time of the two groups. Results 90 cases with acute alcoholism were complete recovery. The waking time in treatment group and the control group was respectively (2.1±2.7) and (3.8±2.5) hours. There was a signiifcant difference between the two groups (P<0.05). The complete recovery time in treatment group and the control group was respectively (4.7±3.8) and (6.2±4.3) hours. There was a signiifcant difference between the two groups (P<0.05). Conclusion The clinical efifcacy of naloxone combined with Xingnaojing injection is better than naloxone therapy alone to patients with acute alcoholism. Therefore, the application of Xingnaojing injection is recommended in the cases with acute alcoholism.