【摘 要】
：
Hypoxia,a salient feature of most solid tumors,confers invasiveness and resistance to the tumor cells.Oxygen-consumption photodynamic therapy (PDT) suffers from
【机 构】
：
Wuya College of Innovation, Shenyang Pharmaceutical University, Shenyang 110016, China;School of Pha
论文部分内容阅读
Hypoxia,a salient feature of most solid tumors,confers invasiveness and resistance to the tumor cells.Oxygen-consumption photodynamic therapy (PDT) suffers from the undesirable impediment of local hypoxia in tumors.Moreover,PDT could further worsen hypoxia.Therefore,developing effective strategies for manipulating hypoxia and improving the effectiveness of PDT has been a focus on antitumor treatment.In this review,the mechanism and relationship of tumor hypoxia and PDT are discussed.Moreover,we highlight recent trends in the field of nanomedicines to modulate hypoxia for enhancing PDT,such as oxygen supply systems,down-regulation of oxygen consumption and hypoxia utilization.Finally,the opportunities and challenges are put forward to facilitate the development and clinical transformation of PDT.
其他文献
勐腊县引种优质稻种奉新红成功勐腊县农科所６６６３００任丕荣奉新红，又名柳条红，是传统的地方名贵稻米，笔者于１９９３年引进该稻种在海拔６３５米的勐腊热坝区试种，获得成功，亩产达４２６千克，比参试种显著增产。
Single-particle electron microscopy has now reached maturity, becoming a commonly used method in the examination of macromolecular structure. Using a small amo
Pancreatic cancer is one of the most aggressive cancers with poor prognosis and a low 5-year survival rate.The family of P21-activated kinases (PAKs) appears to
Dysregulation of mTORC1/mTORC2 pathway is observed in many cancers and mTORCl inhibitors have been used clinically in many tumor types;however,the mechanism of
“招９０──８”高产优质玉米新品种最近，一种高产优质玉米新品种“９０一８”在山东招远市培育成功，并通过省市级玉米专家的鉴定。“招９０一８”玉米穗位低，穗下节短，穗上节间长，节片互生，上部呈松
Twelve new grayanoids (1-12) along with five known compounds were isolated from flowers of Rhododendron molle.Their structures were fully characterized using a
Blood-brain barrier (BBB) breakdown and the associated microvascular hyperpermeability are hallmark features of several neurological disorders,including traumat
Psoriasis is characterized by abnormal proliferation of keratinocytes,as well as infiltration of immune cells into the dermis and epidermis,causing itchy,scaly
杂交棉具有产量高、很强的个体生长优势等特点,杂交棉的种植使新疆棉花单产水平有了进一步提高,而新疆一些棉区无霜期短、热量资源有限,严重制约了棉花杂种优势的发挥,且新疆棉区矮密早高产栽培技术体系造成棉花用种量大,大幅增加了杂交棉的种植成本,影响了杂交棉生产的发展。开展杂交棉移栽稀植试验,以避开不利的气候条件影响,充分发挥杂交棉的增产优势；通过杂交棉稀播试验,以减少用种量,充分发挥杂交棉的个体增产优势。
Platinum-based chemotherapy is used for non-small cell lung cancer (NSCLC).However,it has side effects and minimum efficacy against lung cancer metastasis.In th