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地塞米松磷酸盐是一种肾上腺皮质激素类药物，在一定的温度，ｐＨ环境下，地塞米松磷酸钠会水解为难溶药物地塞米格，影响其稳定性。本论文确定了用ＨＰＬＣ法同时测定出地塞米松磷酸钠和其水解产物地塞米松的色谱条件；研究了药物载体羟丙基－β－环糊精（ＨＰ－β－ＣＤ）存在及不存在条件下地塞米松磷酸盐的水解行为．实验结果表明，ＨＰ－β－ＣＤ与水解产物地塞米松发生也接反应后能增加难溶药物地塞米松在水中的溶解度，同时破坏了水解反应的平衡，加速了地塞米松磷酸钠的水解作用。在反应温度６０℃，ｐＨ为７．０时地塞米格磷酸钠的水解速率最小为０．００７Ｄ－１．地塞米格磷酸钠水解产物的液和色谱图结果表明，其水解产物中除地塞米松产物外，还存在其它未知水解产物．
Dexamethasone phosphate is an adrenal cortical hormone drugs, at a certain temperature, pH environment, dexamethasone sodium phosphate hydrolysis will be difficult to dissolve the drug Secretize, affecting its stability. In this paper, we determined the chromatographic conditions of simultaneous determination of dexamethasone sodium phosphate and its hydrolyzate dexamethasone using HPLC method. The presence and absence of the drug carrier hydroxypropyl-β-cyclodextrin (HP-β-CD) Hydrolysis behavior of dexamethasone phosphate. The experimental results show that HP-β-CD and hydrolyzate dexamethasone also increase the solubility of dexamethasone dissolved in water after the reaction, at the same time undermining the hydrolysis reaction equilibrium, accelerating the hydrolysis of dexamethasone sodium phosphate effect. The hydrolysis rate of dexamethasone sodium phosphate was 0.007D-1 at the reaction temperature of 60 ℃ and pH 7.0. Dexamet & lt; / RTI & gt; sodium phosphate hydrolyzate solution and chromatogram results show that in addition to dexamethasone product hydrolyzate, there are other unknown hydrolyzate.