近年来，人们对Ｂ细胞的免疫应答的本质，生发中心的形成，细胞克隆的发生和发育，抗原细胞细胞相互作用，以及不同的Ｂ细胞亚群的调节，在分子水平上加又以重新认识。从而推动了对自身免疫病中Ｂ细胞的超突变、克隆性增生的研究。来自骨髓的Ｂ细胞迁移至外周淋巴组织如淋 In recent years, the nature of the immune response to B cells, the formation of germinal center, the occurrence and development of cell clones, the antigen-cell-cell interaction, and the regulation of different B cell subsets, at the molecular level, Re-recognize. So as to promote the autoimmune disease B cell hypermutation, clonal hyperplasia research. B cells from the bone marrow migrate to peripheral lymphoid tissues such as leaching