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目的：通过检测人胎盘型谷胱甘肽Ｓ转移酶（ＧＳＴπ）在胃癌和胃癌前病变组织中的表达情况，研究胃癌与ＧＳＴπ之间的关系。方法：用Ｓ－Ｐ法免疫组化技术检测了ＧＳＴπ在５８例胃癌、２５例胃粘膜肠上皮化生、２８例胃粘膜不典型增生和３９例正常胃粘膜组织中的表达情况。结果：胃癌、胃粘膜肠上皮化生和胃粘膜不典型增生组织中ＧＳＴπ表达阳性率依次为７７６％（４５／５８）、７６０％（１９／２５）和８９３％（２５／２８），而正常胃粘膜组织仅１０３％（４／３９）呈微弱阳性。在胃癌标本中，高分化腺癌、低分化腺癌、粘液腺癌和印戒细胞癌的阳性率依次为８３３％（１０／１２）、８９３％（２５／２８）、６６７％（６／９）、２５０％（１／４）和６００％（３／５）。可见ＧＳＴπ在胃癌及癌前病变组织中的表达较正常胃粘膜高（Ｐ＜００１）；分化较好的腺癌高于分化较差的腺癌。结论：ＧＳＴπ有胃癌及癌前病变中的表达与胃癌的发生发展密切相关，ＧＳＴπ的免疫组化检测可作为胃癌及癌前病变诊断的一项有价值的指标
Objective: To investigate the relationship between gastric cancer and GST-π by detecting the expression of human placental glutathione S-transferase (GST-π) in gastric cancer and precancerous lesions. METHODS: The expression of GST-π in 58 cases of gastric cancer, 25 cases of intestinal metaplasia of gastric mucosa, 28 cases of dysplasia of gastric mucosa and 39 cases of normal gastric mucosa were detected by immunohistochemistry with S-P method. RESULTS: The positive rates of GST-π expression in gastric cancer, gastric mucosal intestinal metaplasia and gastric dysplasia were 77.6% (45/58), 76.0% (19/25), and 89. 3% respectively. (25/28), while normal gastric mucosa was only slightly positive at 10% 3% (4/39). In gastric cancer specimens, the positive rates of well-differentiated adenocarcinoma, poorly differentiated adenocarcinoma, mucinous adenocarcinoma, and signet-ring cell carcinoma were 83. 3% (10/12), 89. 3% (25/28), and 66. 7% (6/9), 250% (1/4) and 600% (3/5). It can be seen that the expression of GST-π in gastric cancer and precancerous lesions is higher than that in normal gastric mucosa (P<001); Adenocarcinomas with better differentiation are higher than those with poor differentiation. Conclusion: The expression of GSTπ in gastric cancer and precancerous lesions is closely related to the occurrence and development of gastric cancer. GSTπ immunohistochemistry can be used as a valuable indicator in the diagnosis of gastric cancer and precancerous lesions.