已知HBsag除从血液、肝脏等脏器检出外,在粪便、尿液、唾液、腹水、汗液、母乳、羊水、关节液和精液内都有检出。从脑脊液中检出HBsAg的报道,仅见日本(1974)有1例(国外医学参考资料内科分册,1:38,1976),国内尚未有过报告。我院于1977年从1例血液HBsAg阳性的脑膜炎患者的脑脊液中检出HBsAg,现将该病例报告如下:顾××,男,18岁,因发热、头痛一个半月,于1977年9月24日由外院以病毒性脑膜炎转来我院。既往无肝病史,家属中亦无肝病患者。入院后第三天,经脑脊液涂片和培养获得新生隐球菌,证实为新生隐球菌脑膜炎。在两性霉素乙治疗开始前,血清检查肝功能正常,HBsAg及 HBsag is known to be detected in stool, urine, saliva, ascites, sweat, breast milk, amniotic fluid, synovial fluid, and semen, in addition to being detected in blood, liver and other organs. HBsAg was detected from cerebrospinal fluid, but only one case was found in Japan (1974) (Foreign Medical Reference Materials, 1: 38,1976). There have been no reports in China yet. Our hospital in 1977 from a case of HBsAg positive meningitis in patients with cerebrospinal fluid HBsAg detection, the case is now reported as follows: Gu × ×, male, 18 years old, due to fever, headache for 1.5 months in September 1977 On the 24th by the outer hospital with viral meningitis transferred to our hospital. No past history of liver disease, no liver disease in family members. On the third day after admission, Cryptococcus neoformans was obtained from cerebrospinal fluid smear and culture, confirming Cryptococcus neoformans meningitis. In the amphotericin B treatment before the start of the serum to check the normal liver function, HBsAg and