目的探讨中老年脑白质疏松症(leukoaraiosis,LA)与同型半胱氨酸(Homocysteine,Hcy)、叶酸及维生素B12的相关性。方法选择CT、MRI证实的中老年LA患者30例,测定其血浆总Hcy、血清叶酸及维生素B12水平,与对照组比较。结果中老年LA患者血浆总Hcy升高,血清叶酸、维生素B12降低,与对照组相比差异有统计学意义(P<0.001),即Hcy水平与中老年LA呈正相关,叶酸、维生素B12水平与中老年LA呈负相关。结论Hcy、叶酸及维生素B12与中老年LA具有相关性,是中老年LA的重要危险因素。 Objective To investigate the relationship between leukoaraiosis (LA) and homocysteine ​​(Hcy), folic acid and vitamin B12 in middle aged and senile patients. Methods Thirty patients with middle-aged and elderly patients with LA confirmed by CT and MRI were enrolled in this study. Total plasma Hcy, serum folate and vitamin B12 levels were measured and compared with those of the control group. Results The plasma total Hcy of middle-aged and elderly patients with LA increased, while the levels of serum folic acid and vitamin B12 decreased. There was a significant difference between the control group and the control group (P <0.001) Middle-aged LA was negatively correlated. Conclusions Hcy, folic acid and vitamin B12 are associated with middle-aged and elderly LA, which are important risk factors for middle-aged and elderly LA.