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目的： 探讨不同声学造影剂剂量在肝脏 ＶＸ２ 肿瘤显影中的增强效果及变化规律。方法： １３ 只患有ＶＸ２ 肝肿瘤的新西兰白兔分别经外周静脉注射氟碳声学造影剂０．０１、０．０２、０．０４ｍ ｌ／ｋｇ， 按常规连续显像和延迟显像方式然后用高频基波显像和二次谐波显像观察肿瘤造影效果。结果： 基波显像在０．０１、０．０２、０．０４ 剂量水平产生的视觉肿瘤显影评分显著低于二次谐波显像 （Ｐ＜ ０．０１）， 基波显像在０．０１、０．０２、０．０４ 剂量水平产生的肿瘤显影视频密度值分别为２３．２３±７．５４、４０．０２±１０．１８ 和４３．７８±１０．４， 二次谐波显像的对应值是６５．５５±１１．３３、８７．８３±１７．０３和１１２．１６±２３．３８ （Ｐ＜ ０．０１）。结论： 声学造影剂量－效应关系在二次谐波显像中变化敏感， 在基波显像中变化相对不敏感。
Objective: To investigate the enhancement effect and variation of different contrast agent doses in the development of liver VX2 tumors. Methods: Thirteen New Zealand white rabbits with VX2 liver tumors were injected with fluorocarbon ultrasound contrast agent 0.01, 0.02, and 0.04 ml/kg via peripheral veins, followed by conventional continuous imaging and delayed imaging. High-frequency fundamental imaging and second harmonic imaging were used to observe the effect of tumor imaging. RESULTS: Visual tumor development scores at 0.01, 0.02, and 0.04 doses were significantly lower than those of second-harmonic imaging (P<0.01). Fundamental wave imaging was 0. The tumor development video density values at 01, 0.02, and 0.04 dose levels were 23.23±7.54, 40.02±10.18, and 43.78±10.4, respectively, and the second harmonic imaging The corresponding values were 65.55±11.33, 87.83±17.03, and 112.16±23.38 (P<0.01). Conclusions: The dose-response relationship in contrast imaging is sensitive to changes in second harmonic imaging and relatively insensitive to changes in fundamental imaging.