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阻塞性睡眠呼吸暂停低通气综合征(OSAHS)是临床常见的慢性睡眠呼吸障碍性疾病。已有多项研究证实OSAHS与高血压密切相关,是高血压的独立危险因素之一。OSAHS引起持续高血压的原因尚不完全清楚,但多数学者认为,可能与OSAHS患者的睡眠结构紊乱致低氧血症、高碳酸血症刺激中枢和外周化学感受器导致交感神经系统兴奋,释放了较多的去甲肾上腺素,内皮素水平增高,内皮细胞依赖性血管释放因子减少,血管平滑肌严重肥厚并发生重构有关。OSAHS患者血压的大幅度波动,激活肾素-血管紧张素-醛固酮系统(RAAS)系统炎症因子增加,进一步导致了血管内皮功能紊乱。OSAHS常常引起持续性、难治性高血压,长期血压控制不佳更易并发靶器官损害。
Obstructive sleep apnea-hypopnea syndrome (OSAHS) is a common chronic sleep apnea disorder. A number of studies have confirmed that OSAHS is closely related to hypertension and is an independent risk factor for hypertension. OSAHS caused by persistent hypertension is not yet fully understood, but most scholars believe that OSAHS patients with sleep disorders may cause hypoxemia, hypercapnia stimulated central and peripheral chemoreceptors lead to sympathetic nervous system excitement, the release of more More norepinephrine, increased endothelin levels, endothelial-dependent vascular release factor decreased, severe vascular smooth muscle hypertrophy and remodeling related. Large fluctuations in blood pressure in OSAHS patients and an increase in inflammatory factors in the activated renin-angiotensin-aldosterone system (RAAS) system further lead to endothelial dysfunction. OSAHS often causes persistent, refractory hypertension, long-term poor blood pressure control and more likely to target organ damage.