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目的观察参芪五味子片联合化疗治疗晚期乳腺癌的临床疗效。方法将60例患者采用数字表法随机分为试验组(30例)与对照组(30例)。两组均采用相同的CTF方案化疗,试验组同时加用参芪五味子片治疗,2l天为1个周期,2个周期评价疗效。观察近期疗效、中医证候变化、生活质量变化、不良反应等。结果试验组与对照组近期总缓解率分别为50.0%、43.3%,两组比较差异无统计学意义(P>0.05)。临床证候改善率分别为70.0%、46.7%,两组比较差异有统计学意义(P<0.05);生活质量改善率分别为76.7%、50.0%,两组比较差异有统计学意义(P<0.05);不良反应发生率试验组低于对照组(P<0.05)。结论参芪五味子片能减轻化疗造成的骨髓抑制,改善临床症状,提高生活质量,延长生存期。
Objective To observe the clinical efficacy of Shenqi Schisandra tablets combined with chemotherapy in the treatment of advanced breast cancer. Methods Sixty patients were randomly divided into experimental group (30 cases) and control group (30 cases) by digital table method. Both groups were treated with the same CTF chemotherapy, while the treatment group was treated with Shenqi Schisandra tablets. The treatment period was 2 days for 1 day and 2 cycles for evaluation. Observation of short-term efficacy, TCM syndrome changes, quality of life changes, adverse reactions. Results The total remission rates of the trial group and the control group were 50.0% and 43.3% respectively, with no significant difference between the two groups (P> 0.05). The clinical improvement rate was 70.0% and 46.7%, respectively, with significant difference between the two groups (P <0.05). The quality of life improvement rates were 76.7% and 50.0% respectively, with significant difference between the two groups (P < 0.05). The incidence of adverse reactions in the experimental group was lower than that in the control group (P <0.05). Conclusion Shenqi Schisandra tablets can reduce bone marrow suppression caused by chemotherapy, improve clinical symptoms, improve quality of life and prolong survival.