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1955年,Somlo首先报道三磷酸腺苷(ATP)成功终止室上速。随后,腺苷与ATP一度成为终止室上速的首选药物,而ATP试验主要用于阵发性心动过速的鉴别诊断。[试验方法]ATP试验主要用于宽或窄QRS波心动过速的诊断与鉴别诊断。给药前,先建立静脉通道,将0.2～0.25mg/kg的ATP稀释成3～5ml后快速推注,随后用生理盐水迅速将药物完全推送到受试者的静脉中,全程监测心电图并记录。[试验机制]ATP属于短效房室结阻滞剂,主要受体为A1受体,该受体在房室结细胞分布最多、最广,故快速推注后可引起短暂的房室传导阻滞。
In 1955, Somlo first reported that adenosine triphosphate (ATP) successfully terminated the supraventricular tachycardia. Subsequently, adenosine and ATP were once the drug of choice for the termination of supraventricular tachycardia, and ATP test is mainly used for the differential diagnosis of paroxysmal tachycardia. [Test Methods] ATP test is mainly used for wide or narrow QRS tachycardia diagnosis and differential diagnosis. Before administration, the first to establish intravenous access, 0.2 ~ 0.25mg / kg of ATP diluted to 3 ~ 5ml after rapid bolus injection, and then quickly with saline to push the drug completely to the subject’s vein, the entire monitoring of ECG and record . [Experimental Mechanism] ATP is a short-acting atrioventricular blocker, the main receptor for the A1 receptor, the receptor in the atrioventricular node cells most widely distributed, so the rapid bolus injection can cause a brief atrioventricular conduction resistance Hysteresis