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目的探究抗菌药物的药源性肺损害及药学监护方法。方法回顾性分析我院2008年1月—2011年12月收治的出现药源性肺损害患者的临床资料,探讨造成伤害的抗菌药物类型,总结药学监护方法。结果出现药源性肺损害的患者中,哮喘的发生率为93.8%,各种药物导致不良反应的症状、例数等比较差异均无统计学意义(P>0.05)。结论合理应用抗菌药物、建立有效的药学监护系统、减少药源性肺损害的发生率,是当今医药工作者的基本任务。
Objective To investigate drug-induced lung injury and drug monitoring methods of antimicrobial agents. Methods The clinical data of patients with drug-induced lung injury admitted in our hospital from January 2008 to December 2011 were analyzed retrospectively to investigate the types of antimicrobial agents that cause injury and to summarize the methods of drug monitoring. Results In patients with drug-induced lung injury, the incidence of asthma was 93.8%. There were no significant differences in the symptoms and number of adverse reactions caused by various drugs (P> 0.05). Conclusion The rational application of antimicrobial agents, the establishment of effective drug monitoring system and reduce the incidence of drug-induced lung injury is the basic task of today’s medical workers.