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目的探讨子宫内膜着床窗口期galectin-3表达与体外受精-胚胎移植(IVF-ET、简称IVF)妊娠结局相关性。方法我院接受IVF治疗患者,于IVF治疗前一周期,监测卵泡发育至1.8-2.0cm时,阴道超声检测子宫内膜厚度、形态;于排卵后6-7天(着床窗口期)取子宫内膜,采用RT-PCR技术检测galectin-3m RNA表达,评价其与妊娠结局的相关性。结果 378例IVF患者,生化妊娠45例。临床妊娠后自然流产34、活胎分娩141例。比较各组内膜厚度和三线型比例无统计学差异,活胎分娩组子宫内膜着床窗口期galectin-3的表达明显高于临床妊娠后自然流产组。结论子宫内膜着床窗口期galectin-3的表达IVF预示妊娠良性结局;子宫内膜厚度和形态不能作为妊娠良性结局的预测因素。
Objective To investigate the correlation between the expression of galectin-3 at the window of endometrial implantation and the pregnancy outcome of IVF-ET (IVF-ET). Methods IVF treatment of patients in our hospital, in the first cycle of IVF treatment, monitoring follicular development to 1.8-2.0cm, vaginal ultrasound detection of endometrial thickness, morphology; 6-7 days after ovulation (implantation window) take the uterus Intima, galectin-3m RNA expression was detected by RT-PCR to evaluate its correlation with pregnancy outcome. Results 378 cases of IVF patients, 45 cases of biochemical pregnancy. Spontaneous abortion after clinical pregnancy 34, 141 cases of childbirth. There was no significant difference in the thickness of intima and the ratio of trigeminal line in each group. The expression of galectin-3 in endometrial implantation window group was significantly higher than that in spontaneous abortion group after clinical pregnancy. Conclusion The expression of galectin-3 in the window of endometrial implantation predicts the benign outcome of pregnancy. The thickness and morphology of endometrium can not be used as a predictor of benign pregnancy outcome.