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目的研究ＰｒｅＳ２抗原与乙型肝炎患者ＨＢＶ标记的关系．方法血清ＨＢｓＡｇ（＋），ＨＢｅＡｇ（＋），ＨＢｃＡｂ（＋）的乙型肝炎患者２６例，血清ＨＢｓＡｇ（＋），ＨＢｅＡｂ（＋），ＨＢｃＡｂ（＋）的乙型肝炎患者４７例及健康献血者２０例，血清用ＲＩＡ法检测ＰｒｅＳ２抗原及用ＰＣＲ法检测ＨＢＶＤＮＡ．结果血清ＨＢｓＡｇ（＋），ＨＢｅＡｇ（＋），ＨＢｃＡｂ（＋）的乙型肝炎患者２６例，ＰｒｅＳ２抗原与ＨＢＶＤＮＡ均阳性（１００％）；血清ＨＢｓＡｇ（＋），ＨＢｅＡｂ（＋），ＨＢｃＡｂ（＋）的乙型肝炎患者４７例，ＰｒｅＳ２抗原３０例阳性（６３８％），１７例阴性（３６２％），ＨＢＶＤＮＡ３２例阳性（６８１％），１５例阴性（３１９％），ＰｒｅＳ２抗原与ＨＢＶＤＮＡ均阳性２８例（５９６％），均阴性１４例（３００％）．健康献血者２０例，ＰｒｅＳ２抗原阳性１例（５０％），阴性１９例（９５０％），ＨＢＶＤＮＡ阳性２例（１００％），阴性１８例（８００％），ＰｒｅＳ２抗原及ＨＢＶＤＮＡ均阳性０例（０％），均阴性１８例（８００％）．结论ＰｒｅＳ２抗原可作为预测慢性乙型肝炎患者病情活动与传染的标志．
Objective To study the relationship between PreS2 antigen and HBV markers in hepatitis B patients. Methods Totally 26 hepatitis B patients with serum HBsAg (+), HBeAg (+) and HBcAb (+), 47 patients with hepatitis B with serum HBsAg +, HBeAb + and HBcAb + Twenty patients were diagnosed as Pre-S2 antigen by RIA and HBVDNA by PCR. Results Serum HBsAg (+), HBeAg (+), HBcAb (+) in 26 patients with hepatitis B, Pre S2 antigen and HBVDNA were positive (100%); serum HB sAg (+), HBeAb There were 47 cases of HBcAb (+) hepatitis B patients, 30 cases of positive Pre-S2 antigen (63.8%), 17 cases of negative (36.2%), 32 cases of positive HBVDNA (68.1%) and 15 cases of negative 31 9%), Pre S2 antigen and HBVDNA were positive in 28 cases (59 6%), were negative in 14 cases (30 0%). There were 20 healthy donors (PreO 2 positive), 1 PreS2 negative (50%), 19 negative (950%), 2 positive HBVDNA (100%) and 18 negative (800% , Pre-S2 antigen and HBVDNA were positive in 0 cases (0%), were negative in 18 cases (80 0%). Conclusion Pre S2 antigen can be used as a marker of disease activity and transmission of chronic hepatitis B patients.