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目的研究7-氧-苄基-1,2∶3,4-二-氧-异亚丙基-α-D-半乳庚糖的实用合成路线。方法以D-半乳糖为原料,通过异丙叉化、Swern氧化、Wittig反应、Os O_4氧化、亲核取代等5步反应制备目标物。结果与结论将目标化合物的结构与已知物的~1HNMR数据对比得到确证,5步总收率为42.4%,操作简便,易于实施,可为后续砂优杆菌抗原活性多糖片段Strain T19的合成奠定基础。
Aim To study the practical synthetic route of 7-oxo-benzyl-1,2: 3,4-dioxo-isopropylidene-α-D-galactopyranose. Methods D-galactose was used as the starting material to prepare the target compound by 5 steps including isopropylation, Swern oxidation, Wittig reaction, Os O 4 oxidation and nucleophilic substitution. RESULTS AND CONCLUSION The structure of the target compound was confirmed by the ~ 1H NMR data of the known compounds. The overall yield in 5 steps was 42.4%. The method was simple and easy to operate and could be applied to the synthesis of Strain T19, basis.